Hyperhomocysteinemia, a Cardiac Metabolic Disease

Hyperhomocysteinemia, a cardiac metabolic disease: role of nitric oxide and the p22phox subunit of NADPH oxidase.

BACKGROUND Hyperhomocysteinemia (HHcy) is a reliable indicator of cardiovascular disease, in part because of the production of superoxide and scavenging of nitric oxide (NO). The present study assessed the impact of HHcy on the NO-dependent control of cardiac O2 consumption and examined enzymatic sources of superoxide. METHODS AND RESULTS Rats and mice were fed methionine in drinking water fo...

Hyperhomocysteinemia, a Cardiac Metabolic Disease Role of Nitric Oxide and the p22 Subunit of NADPH Oxidase

Background—Hyperhomocysteinemia (HHcy) is a reliable indicator of cardiovascular disease, in part because of the production of superoxide and scavenging of nitric oxide (NO). The present study assessed the impact of HHcy on the NO-dependent control of cardiac O2 consumption and examined enzymatic sources of superoxide. Methods and Results—Rats and mice were fed methionine in drinking water for ...

Myriad Cardiac Manifestation of Hyperhomocysteinemia

Homocysteine has been recognized as a risk factor for various cardiovascular manifestations including thrombosis of arterial and venous system, spontaneous dissection involving various vessels in the body including coronaries and aneurysms. Here we report a young gentleman who was diagnosed as stroke in young and found to have dilated cardiomyopathy, with left ventricular dysfunction and hyperh...

Association of Hyperhomocysteinemia with Coronary Artery Disease in Southern Iran

Association of Hyperhomocysteinemia with Coronary Artery Disease in Southern Iran

Background: Differences in the prevalence and impact of hyperhomocytenemia on vascular disease between countries and races have been reported. Most studies have been undertaken in North American and European populations and the importance of plasma total homocysteine (tHcy) level as a risk factor for coronary artery disease in the Middle East particularly in Iran, however, is not known.  Object...